ML25093A077

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M250408B: Slides - Jadvar - Meeting with the Advisory Committee on the Medical Uses of Isotopes
ML25093A077
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Issue date: 04/08/2025
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M250408B
Download: ML25093A077 (1)


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Overview of ACMUI Activities Hossein Jadvar, MD, PhD ACMUI Chair/Nuclear Medicine Physician April 8, 2025

Todays Agenda

  • Hossein Jadvar, MD, PhD, ACMUI Chair/Nuclear Medicine Physician

- Overview of ACMUI activities

  • Richard Green, BS Pharm, ACMUI Vice Chair/Nuclear Pharmacist

- Growth in Radiopharmaceutical Therapy 2

Todays Agenda (contd)

  • Michael Folkert, MD, PhD, ACMUI Radiation Oncologist

- ACMUI Review of Training and Experience for Emerging Medical Technologies

  • Statement from the ACMUI Patients' Rights Advocate.

3

Overview of the ACMUI

  • Membership
  • 2024-2025 Topics
  • Current Subcommittees
  • Future 4

Role of the ACMUI

  • Advise the U.S. Nuclear Regulatory Commission (NRC) staff on policy & technical issues that arise in the regulation of the medical use of radioactive material in diagnosis & therapy.
  • Comment on changes to NRC regulations & guidance.
  • Evaluate certain non-routine uses of radioactive material.
  • Provide technical assistance in licensing, inspection &

enforcement cases.

  • Bring key issues to the attention of the Commission for appropriate action.

5

ACMUI Membership (13 members)

  • Nuclear Medicine Physician, Chair (Hossein Jadvar, MD, PhD)
  • Nuclear Pharmacist, Vice Chair (Mr. Richard Green)
  • Nuclear Cardiologist (Andrew Einstein, MD, PhD)
  • GSR Radiation Oncologist (Harvey Wolkov, MD)
  • Diagnostic Radiologist (Joanna Fair, MD, PhD)
  • FDA Representative (Michael OHara, PhD) 6 6

ACMUI Membership (13 members)

  • Nuclear Medicine Medical Physicist (Ms. Melissa Martin)
  • Radiation Therapy Medical Physicist (Mr. Zoubir Ouhib)
  • Patients Rights Advocate (Mr. Josh Mailman)
  • Agreement State Representative (Ms. Megan Shober)
  • Healthcare Administrator (Ms. Rebecca Allen)
  • Radiation Safety Officer (Richard Harvey, DrPH) 7 7

ACMUI Consultant

  • Interventional Radiologist (John Angle, MD) 8 8

ACMUI Topics April 2025

  • Y-90 Microsphere Gastrointestinal Deposition Medical Events
  • Generic Process Checklist
  • Training and Experience Requirements for Emerging Medical Technologies 9

9

ACMUI Topics 2024

  • Financial Assurance Requirements for Disposition of Category 1-3 Byproduct Material Radioactive Sealed Sources
  • Report on Nuclear Medicine Injection Extravasations as Medical Events
  • Interim Staff Guidance on Implementation of Training and Experience 10 1

0

ACMUI Topics 2024

  • ACMUI Bylaws Recommendations
  • Akesis Galaxy RTi Unit licensing guidance
  • Eye90 Microsphere Device licensing guidance

1

ACMUI Topics 2024

  • A Review of Prescription Error Reduction Methods
  • Review of Medical Events 12 1

2

Staff Presentations to the ACMUI (2024-2025) 13 1

3

  • Medical Radiation Safety Team Updates
  • Medical events
  • Y-90 Microsphere Medical Events
  • Status of Patient Release Guidance
  • Advanced Act
  • Medical Team Updates

Staff Presentations to the ACMUI (2023-2025)

(contd)

  • Patient Waste Guidance
  • ACMUI Reporting Structure
  • Required and Expanded Ethics Training 14 1

4

Current ACMUI Subcommittees 15 1

5

  • NRC Mission and Medical Use Licensing and Oversight
  • Patient Release Subcommittee
  • Training and Experience for All Modalities Subcommittee
  • Medical Event Reporting and Extravasation Subcommittees
  • Y-90 Microsphere Gastrointestinal Deposition Medical Events

Current ACMUI Subcommittees (cont'd) 16 1

6

  • Emerging Medical Technologies and Rubidium 82 Generator Subcommittee
  • Membership of an Interventional Radiologist

Future

-Provide advice and technical assistance

-Comment on NRC regulations and guidance

-Evaluate uses of radioactive material

-Bring key issues to the attention of the Commission 1

7

Acronyms

  • EMT - Emerging Medical Technologies
  • FDA - U.S. Food & Drug Administration
  • GSR - Gamma Stereotactic Radiosurgery
  • NRC - U.S. Nuclear Regulatory Commission

8